The Angolan international aggravated a knee problem in Monday's training session and pulled out of training as a result.

Consequently, Flavio missed Tuesday's training as he was treated by the club's Physiotherapist Osama Ragai during the morning session and FilGoal.com understands that he will most likely miss the important clash against Sundowns.

The first leg of the last 16 clash ended in a 2-2 draw, in which Flavio scored the second goal for the African champions in Pretoria.

Portuguese coach Manuel Jose will have to decide on Flavio's fitness before the crunch game on Friday, as his possible replacement could be Osama Hosni.