The Rossoneri, who won two Champions League titles in five years, will have a tough task against an in-form Arsenal side, who top the Premiership standings.

Italian champions Inter also got an unfavorable draw, having been paired with Liverpool. Rafael Benitez's men always prove to be formidable in knock-outs.

Spanish giants Barcelona will be pleased with the outcome of the draw as they were paired against Scottish champions Celtic.

Although Celtic are difficult to beat at home, they aren't likely to make an upset against the star-studded Barcelona.

Real Madrid, who hold the record for the most Champions League triumphs with nine titles, face the ambitious Roma.

Premiership holders Manchester United will play French counterparts Lyon as they aim to capture Europe's premier competition for the first time since 1999.

Chelsea, who reached the semi-finals three times in the last four seasons, tackle Greek side Olympiakos.

Round of 16 will also witness a relatively balanced contest between Germany's Schalke and Portuguese champions Porto.

Sevilla, who won the UEFA Cup two times in a row, take on Turkish side Fenerbahce.