The first legs will be played on January ninth and the returns a week later.

Barcelona, the 2006 European Champions, and Sevilla, double UEFA Cup winners, have been struggling lately and are far behind Primera Liga leaders Real Madrid.

Real Madrid had a quiet easy draw as they will face Real Mallorca. It is the first time in the history of the tournament that only first division clubs have made it to the last 16.

The full fixtures:

Sevilla - Barcelona

Recreativo Huelva - Villarreal

Real Zaragoza - Racing Santander

Mallorca - Real Madrid

Athletic Bilbao - Espanyol

Real Betis - Valencia

Atletico Madrid - Valladolid