Italy only qualified for the last eight thanks to second-string Dutch team's 2-0 victory over Romania and their 2-0 win against France in the last round of Group C.
But Italy have their reasons to be optimistic as they have a habit of starting slowly but coming to the boil when it really matters.
To the contrast, Spain, who had scored three straight victories in group stages, had often faded quickly in knockout stages of major tournaments after making promising start in group stages.
In 2006 World Cup, Spain looked unbeatable in early stages but were stopped abruptly by France.
"This team have learned a lot since the World Cup," said midfielder Xabi Alonso, "We were a young side then and now we know what these competitions are like."
Italy will have to reshuffle their line-up due to the suspensions of midfielders Gennaro Gattuso and Andrea Pirlo.
Massimo Ambrosini and Mauro Camoranesi should replace them in midfield while Antonio Cassano is likely to start alongside Luca Toni up front.
Spain coach Luis Aragones admitted that he is wary of the world champions though they looked in poor form in the group stage.
"They aren't the team I would have most liked to have met. Defensively they are almost perfect," said Aragones.
"We all know what Italy are like and it is not for nothing that they are world champions.
"That tells us everything. They seemed dead and buried and now they are in the quarter-finals. Italy know how to cope with the good and bad times and their history shows that they have some enormously talented and hard-working players," added Aragones.
Spain will have to overcome the psychological obstacle that they have never beaten Italy at the finals of a major international tournament.
As the quarterfinal clash will be played on June 22 in Vienna, the Spanish team will have to break the June 22 jinx -- they fell three times in major tournament knockout stages on that date.
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قصة التوأم - رفض سيلتك ولاتسيو من أجل الأهلي.. والاستقرار على تشكيل مصر في كأس العالم
منتخب الشباب يفوز أمام عمان وديا.. وإنقاذ لاعب بعد بلع لسانه
الشريعي يكشف سبب رحيل حمزة الجمل.. وحقيقة عروض عبد الله وأقطاي وعلي محمود
استعدادا للقاء المصري.. الأهلي ينتصر على دلفي بثنائية وديا
مران الزمالك - تخفيف الأحمال قبل نهائي الكونفدرالية.. وموعد المؤتمر الصحفي
محمد حمدي يبدأ المرحلة الثالثة من التأهيل للتعافي من إصابة الرباط الصليبي
أمير عزمي مجاهد: أهدي التأهل للممتاز إلى والدي.. وأكملت ما بدأه الكناني مع أبو قير
خالد جلال: الإسماعيلي سيندثر إذا هبط.. وسنعود لدوري يشبه فترة كورونا












بقيادة معلول والمثلوثي.. الصفاقسي يحجز المركز الثالث محليا ويتأهل للكونفدرالية