Juanma Mata cancelled out Ruud van Nistelrooy's early opener shortly after the break.

Three minutes later Mata turned provider as he delivered a fine cross to EURO 2008 top scorer David Villa who powered a header past Iker Casillas.

But once again Van Nistelrooy levelled when he fired a first-time volley in the 68th minute to make it 2-2.

Eight minutes from time, substitute Vicente scored the decider to give Los Ches an advantage before the return leg next Sunday at the Bernabeu.