Holland will miss striker Robin Van Persie when they entertain Iceland in the 2010 World Cup qualifier in Rotterdam on Saturday.

The Arsenal striker is nursing a hamstring injury, but could still catch up with the Oranje's trip to Norway next week.

Van Persie joins injury-prone Real Madrid winger Arjen Robben and Celtic striker Jan Vennegoor of Hesselink, who were both ruled out with injuries.

Defender John Heitinga is also struggling with a knee injury, as Jan Kromkamp is likely to be his replacement.