Hamza suffered a knee injury in Saturday's 1-0 defeat at Ittihad, where the 27-year-old came on as a second half substitute.

"Gamal will be subjected to extensive treatment in an attempt to have him fit by Wednesday, but I think it will be very difficult," Zamalek medical chief Mostafa Monairi said.

Zamalek's defeat in Alexandria saw them slumping to eighth place in the league table, only three points off the relegation zone.

The beleaguered Cairo club are now set to face another tough challenge on Wednesday against Masri, who were marginally beaten by leaders Ahli on Saturday.