Villarreal's official site stated that the Spain international, who superbly scored his side's only goal in last week's first-leg 1-1- draw with the Gunners, limped off the 2-0 Liga defeat to Malaga on Saturday.

The Primera Liga outfit added that Senna will undergo further tests on Sunday, but conceded that the 32-year-old is unlikely to be fit for the midweek tie.

Senna's injury comes as a blow for the Yellow Submarines, who already lost influential winger Santi Cazorla for the rest of the season with a broken leg.

"Our injury problems are making life difficult," said manager Manuel Pellegrini.