The Dutch striker is nursing a niggling groin injury and is definitely ruled out of Wednesday's clash at Old Trafford.

"He is definitely out for Sunday (against Middlesbrough) and for Manchester United," Arsenal boss Wenger told the club's official website.

Van Persie joins French duo William Gallas and Gael Clichy in the Gunners' injury list, whereas goalkeeper Manuel Almunia could return against United.