The 30-year-old, who was released by Ahli last week, penned a two-year deal after passing a medical at Zamalek.
Mostafa is looking to revive his career after two disappointing seasons with Ahli, where he struggled with fitness and form.
"I am very happy to be a Zamalek player. I hope this move can help me regain my form and then I could return to the national team," the combative midfielder told FilGoal.com.
"I have to mention the great spell I had with Ahli and I don’t want the fans to be upset because I joined their rivals."
On the other hand, Zamalek are overhauling their midfield after failing to find a reliable player in that position during the past few years.
They released veteran midfielder Mohamed Aboul-Ella and brought in Ghanaian international Ibrahim Ayew and Ahmed Tharwat, who joined from second-division side Rabat.
نرشح لكم
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الزمالك يعود للتدريبات.. وتصعيد ثنائي الشباب











