The Tunisian side played out a 2-2 draw at APR in the first leg before registering the empathic home win to go through on a 6-2 aggregate victory.

Zamalek qualified for the round of 32 after beating Ulinzi Stars 4-0 and 1-0 in both legs.

Africain and Zamalek were widely expected to meet at this stage of the Champions League.