United, who held Real to a 1-1 draw in Madrid, took the lead through a Sergio Ramos own goal before the referee harshly sent off Nani for an alleged dangerous play.

The one-man advantage allowed Luka Modric and Ronaldo to score two quick goals and settle the tie.

Elsewhere, Borussia Dortmund eased to the quarter-finals with a 5-2 aggregate win over Shakhtar Donetsk, with Felipe Santana, Mario Gotze and Jakub Blaszczykowski scoring in a 3-0 home victory on the night.

United 1-2 Real

Dortmund 3-0 Shakhtar