كتب : Hatem Maher
The Egypt striker pulled out of Sunday's training session after complaining of a hamstring pain.
Zaki has been hit by a string of injuries recently. He made a substitute appearance in the 2-1 victory over Ghazl Mahalla but will now have to sit out Al-Hodoud match.
Beshir Al-Tabie and Mahmoud Fathallah added to Zamalek's defensive crisis.
The duo hasn't made the squad due to injury to join long-term absentee Wissem El-Abdi on the sidelines.
Veteran striker Abdul-Halim Ali returns after being snubbed against Mahalla for an undisclosed reason.
Zamalek squad:
Goalkeepers: Abdul-Wahed Al-Sayed, Mohamed Abdul-Monsef
Defenders: Amr Al-Safti, Ahmed Magdi, Karim Zekri, Ahmed Hossam, Ahmed Ghanem, Mohamed Abdullah, Ahmed Ibrahim
Midfielders: Magdi Attwa, Mohamed Aboul-Ella, Ahmed Abdul-Raouf, Mohamed Ibrahim, Shikabala, Hazem Emam
Strikers: Gamal Hamza, Sherif Ashraf, Abdul-Halim Ali